I always prefer an aisle seat because I want to be in control of my own destiny. I can lean into the aisle for extra room (but watch the drink cart!) and I can get up for the lavatory whenever I wish. Crucially, I also have at least one armrest I don’t have to fight for.
This means giving up being able to gaze out the window (lost Instagram opportunity), and an obligation to get up when someone else wants to use the restroom, but those are easy tradeoffs.