Most US citizens want Global Entry because it includes PreCheck, for an extra $15 gets expedited immigration (of decreasing importance as immigration kiosks roll out), and it reimbursed by more premium credit cards than PreCheck. Frequent Canadian visitors should get Nexus, and it’s cheaper, but the waits and dual approvals may discourage.
Here’s the rub in all of this. Wait times. If you sign up for Global Entry now, you may not get it this year.