Star Allinace member Turkish Airlines has opened up as many as 8 business class award seats or more between the US and Istanbul in 2016. This is available on a wide range of dates.
Turkish serves more countries in the world than any other airline (and fourth most destinations and will provide a free hotel night in Istanbul if flight schedules force an overnight connection in Istanbul. You can generally route US – Istanbul on Turkish and then backtrack to Western Europe. They’re a great option for getting to Israel and to Athens, as well as to Africa and even Asia.